Excessive beta-adrenergic stimulation has been associated with central nervous system and cardiovascular effects.
As with other inhaled medications, paradoxical bronchospasm may occur with SYMBICORT.Caution should be exercised when considering administration of SYMBICORT in patients on long-term ketoconazole and other known potent CYP3A4 inhibitors.Deaths due to adrenal insufficiency have occurred in asthmatic patients during and after transfer from systemic corticosteroids to less systemically available ICS Particular care is needed for patients who are transferred from systemically active corticosteroids to ICS. It is possible that systemic corticosteroid effects such as hypercorticism and adrenal suppression may occur, particularly at higher doses.A more serious or even fatal course of chickenpox or measles can occur in susceptible patients Due to possible immunosuppression, potential worsening of infections could occur.Lower respiratory tract infections, including pneumonia, have been reported following the administration of ICS.Patients should rinse the mouth after inhalation of SYMBICORT Localized infections of the mouth and pharynx with Candida albicans has occurred in patients treated with SYMBICORT.Patients who are receiving SYMBICORT should not use additional formoterol or other LABA for any reason.SYMBICORT should not be initiated in patients during rapidly deteriorating episodes of asthma or COPD.SYMBICORT is NOT a rescue medication and does NOT replace fast-acting inhalers to treat acute symptoms.When LABA are used in fixed dose combination with ICS, data from large clinical trials do not show a significant increase in the risk of serious asthma-related events (hospitalizations, intubations, death) compared to ICS alone These findings are considered a class effect of LABA. Available data from controlled clinical trials also suggest that use of LABA as monotherapy increases the risk of asthma-related hospitalization in pediatric and adolescent patients. Use of long-acting beta 2-adrenergic agonists (LABA) as monotherapy (without inhaled corticosteroids ) for asthma is associated with an increased risk of asthma-related death.Also, with identify theft becoming more and more common, it is generally a good idea to think twice before providing any personal information. Before you provide any information to any of the linked websites, we recommend that you take steps to confirm the identity of the entity requesting the information before continuing. In some cases, the linked website may ask for your contact information before allowing you to print a copay card.
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